APPEAL-9:

How to Build the Biggest and Most Complex Discovery Machines

Applications of Accelerators – APPEAL 9- 30th June 2018

Dr. Suzie Sheehy

John Adams Institute for Accelerator Science

University of Oxford

https://en.wikipedia.org/wiki/Suzie_Sheehy

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https://twitter.com/suziesheehy?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor

https://www2.physics.ox.ac.uk/contacts/people/sheehy

What are accelerators used for?

A beam of particles is a very useful tool…”

-Accelerators for Americas Future Report, pp. 4, DoE, USA, 2011

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About half of the 35,000 accelerators are used for medicine

“A beam of the right particles with the right energy at the right intensity can shrink a tumour, produce cleaner energy, spot suspicious cargo, make a better radial tyre, clean up dirty drinking water, map a protein, study a nuclear explosion, design a new drug, make a heat-resistant automotive cable, diagnose a disease, reduce nuclear waste, detect an art forgery, implant ions in a semiconductor, prospect for oil, date an archaeological find, package a Thanksgiving turkey or… discover the secrets of the universe.”

1. Medical Applications

Around 1/3 of people in the will die from cancer…

But diagnosis is no longer a death sentence!

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Reference: Cancer Services Collaborative 2002 www.nhs.uk/npat

X-ray radiotherapy

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The whole system rotates through 360 degrees around the patient

External beam radiation therapy uses x-rays, or photons, which are sometimes called “packets of energy,” to treat cancer. The higher the energy of the x-ray beam, the deeper the x-rays penetrate into the target tissue. Linear accelerators produce x-rays at various energies.

The large “L-shaped” design of the linear accelerator allows it to rotate, delivering radiation from all angles. Multiple angles allow the maximum amount of radiation to be delivered to the tumour while delivering a minimal amount of radiation to the surrounding healthy tissue.

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Radiation therapy uses high-energy x-rays (ionizing radiation) to stop cancer cells from dividing. A rad is the scientific unit of measure of radiation energy dose. A patient who receives radiation therapy as a treatment for cancer will receive several thousand rads over a very short period of time (weeks or months). A typical x-ray contains far fewer rads. For example, modern mammography systems used to take x-ray images of the breast use approximately 0.1 to 0.2 rad dose per x-ray.

During radiation therapy, x-rays deposit energy in the area being treated, damaging the genetic material of cells and making it impossible for these cells to divide. Although radiation damages both cancer cells and normal cells, the normal cells are usually able to repair themselves and function properly. Like surgery, radiation therapy is a local treatment; it only affects the cells in the treated area. Radiation therapy may be used to treat localized solid tumours, such as cancers of the skin, head and neck, brain, breast, prostate and cervix. Radiation therapy can also be used to treat leukaemia and lymphoma (cancers of the blood-forming cells and lymphatic system, respectively).

http://www.imaginis.com/radiotherapy/how-does-radiation-therapy-work

Radiotherapy access around the world

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Many parts of the work lack the equipment and staff

The annual global incidence of cancer is expected to rise from 15 million cases in 2015 to as many as 25 million cases in 2035.

Of these, it is estimated that 65-70% will occur in low-and middle-income countries (LMICs)

“There is a shortfall of more than 5000 radiotherapy machines in low-to-middle income countries, with patients in some countries in Africa and Asia having almost no access to radiation therapy, much less modern technology and expertise” – IAEA, DIRAC

“…as many as 12,600 megavolt-class treatment machines will be needed to meet radiotherapy demands in LMICs by 2035. Based on current staffing models, it was estimated that an additional 30,000 radiation oncologists, more than 22,000 medical physicists and almost 80,000 radiation technologists will be required.”

CERN hosted a workshop on “Design characteristics of a novel linear accelerator for challenging environments”

https://indico.cern.ch/event/560969/sessions/211066/#20161107

Norman Coleman, David Pistenmaa (ICEC), Manjit Dosanjh (CERN)

International Cancer expert corps. & CERN

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Taskforces to address the challenge

1) Technology (bury the complexity) (a) near term; (b) longterm

2) Education, training and mentoring

3) Global connectivity and development

https://indico.cern.ch/event/560969

https://home.cern/about/updates/2017/11/combatting-cancer-challenging-environments

Can we make a medical LINAC that is cheaper, more robust, easier to maintain, modular and reliable whilst providing state-of-the-art treatment?

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The above picture shows Uganda’s only (now broken) radiotherapy unit

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The above picture shows a modern radiotherapy unit

STFC & Global Challenges Research Fund

1) Study of accelerator technology options

2) Robust permanent magnet beam delivery systems

3) RF power systems and optimized RF structures for electron beam acceleration

4) Linear accelerator simulations for stable and sustainable operation of developing country radiotherapy linear accelerators

5) Cloud-based electronic infrastructure in support of LINAC-based radiotherapy in challenging environments

6) Plus a student (L. Wroe, MPhys) independently awarded funding by Laidlaw Scholarship to study failure modes of medical LINACs

Charged Particle Therapy

X-ray peak just under the skin. Protons can be placed better so the cancer gets most and the healthy tissue gets less. More precision required with protons, which is also more costly than X-rays.

https://www.cancer.net/navigating-cancer-care/how-cancer-treated/radiation-therapy/proton-therapy

https://en.wikipedia.org/wiki/Proton_therapy

https://en.wikipedia.org/wiki/Bragg_peak

The Bragg peak is a pronounced peak on the Bragg curve which plots the energy loss of ionizing radiation during its travel through matter. For protons, α-rays, and other ion rays, the peak occurs immediately before the particles come to rest. This is called Bragg peak, after William Henry Bragg who discovered it in 1903.

https://en.wikipedia.org/wiki/William_Henry_Bragg

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Sir William Henry Bragg OM KBE PRS (2 July 1862 – 12 March 1942) was a British physicist, chemist, mathematician and active sportsman who uniquely shared a Nobel Prize with his son Lawrence Bragg – the 1915 Nobel Prize in Physics: “for their services in the analysis of crystal structure by means of X-rays”.

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Greater dose where needed

Less morbidity for healthy tissue

Less damage to vital organs

Energy loss in materials

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Proton therapy

“Hadron therapy” = Protons and light ions

Used to treat localised cancers

Less morbidity for healthy tissue

Less damage to vital organs

Particularly for childhood cancers

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Medulloblastoma – affects children. Malignant brain tumour is surgically removed and afterwards, to prevent spread, you want to sterilize the spine with radiation.

A few developments

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HEP community can contribute accelerators AND other expertise!

Radioisotope production

Accelerators (compact cyclotrons or linacs) are used to produce radio-isotopes for medical imaging.

7-11MeV protons for short-lived isotopes for imaging

70-100MeV or higher for longer lived isotopes

Positron emission tomography (PET) uses Fluorine-18, half-life of ~110 min

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Right: normal metabolic function in the brain

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Fluorodeoxyglucose or FDG carries the F18 to areas of high metabolic activity

90% of PET scans are in clinical oncology

Radiopharmaceuticals

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2. Industrial accelerators

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Electrostatic accelerators are used to deposit ions in semiconductors.

https://cds.cern.ch/record/1005042/files/p95.pdf

Electron beam processing

http://rsccnuclearcable.com/capabilities.htm

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Shrinks the film around the turkey

Equipment sterilisation

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Food irradiation

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By irradiating food, depending on the dose, some or all of the microorganisms, bacteria, viruses or insects present are killed.

Can be used at low doses to: delay food ripening, quarantine treatment

Medium doses are used to reduce microbes & extend the shelf life of meat, poultry and seafood (refrigerated & frozen) and also reduce microorganisms in spices to improve their shelf life. High dose applications: sterilise meat for NASA astronauts

Other uses in industry…

Hardening surfaces of artificial joints

Removal of NOx and SOx from flue gas emissions

Scratch resistant furniture

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Around 6 tonnes of topaz are irradiated each year. Almost none of the ‘blue’ topaz you’ll find on the market is natural.

http://www.nrc.gov/reading-rm/doc-collections/fact-sheets/irradiated-gemstones.html

http://www.symmetrymagazine.org/article/october-2009/cleaner-living-through-electrons

3. Synchrotron Light Sources

Synchrotron light sources that have begun operation in last 15 years

Image courtesy of ESRF

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Synchrotron radiation is emitted by charged particles when accelerated radially

Produced in synchrotron radiation sources using bending magnets, undulators and wigglers

https://en.wikipedia.org/wiki/Undulator

https://en.wikipedia.org/wiki/Wiggler_(synchrotron)

The choice of magnetic field and oscillatory period affects radiation produced

Altering the undulator gap will vary the harmonic energies.

Wiggler = incoherent but high flux, Undulator = coherent, tunable.

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Above right shows an undulator. An undulator is an insertion device from high-energy physics and usually part of a larger installation, a synchrotron storage ring, or it may be a component of a free electron laser. It consists of a periodic structure of dipole magnets.

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Synchrotron radiation: microwaves to hard x-rays (user can select)

High flux = quick experiments!

Pulsed structure = resolution of processes down to picoseconds

High Flux: high intensity photon beam, allows rapid experiments or use of weakly scattering crystals;

High Brilliance (Spectral Brightness): highly collimated photon beam generated by a small divergence and small size source (partial coherence);

High Stability: submicron source stability

Polarisation: both linear and circular (with IDs)

Pulsed Time Structure: pulsed length down to tens of picoseconds allows the resolution of process on the same time scale

X-Ray crystallography

2014 was the International Year of Crystallography

For some great overview videos of crystallography, see:

http://www.richannel.org/collections/2013/crystallography

Protein crystallography is a standard technique at synchrotron light sources (Diamond light source has 5 beamlines devoted to it)

https://www.diamond.ac.uk/Home.html

The hardest part is forming the crystal…

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Hard condensed matter science

Applied material science

Engineering

Chemistry

Soft condensed matter science

Life sciences

Structural biology

Medicine

Earth and science

Environment

Cultural heritage

Methods and instrumentation

© CCLRC

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Diffraction pattern from pea lectin

Synchrotron Radiation Science

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Above left: The collection of precise information on the molecular structure of chromosomes and their components can improve the knowledge of how the genetic code of DNA is maintained and reproduced

Above right: X-ray fluorescence imaging revealed the hidden text by revealing the iron contained in the ink used by a 10th century scribe, which had since been erased with lemon juice and written over. This x-ray image shows the lower left corner of the page.

4. Neutron Spallation Sources

Neutrons interact best with particles of a similar size

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Metals are transparent as far as neutrons are concerned

https://youtu.be/VESMU7JfVHU?t=21

‘Neutrons tell you where atoms are and what atoms do’

https://en.wikipedia.org/wiki/Spallation

Spallation is a process in which fragments of material (spall) are ejected from a body due to impact or stress.

https://upload.wikimedia.org/wikipedia/commons/1/16/Spallation.gif?download

https://en.wikipedia.org/wiki/Spallation#Nuclear_spallation

Nuclear spallation is one of the processes by which a particle accelerator may be used to produce a beam of neutrons. A particle beam consisting of protons at around 1 GeV are shot into a target consisting of mercury, tantalum, lead or another heavy metal. The target nucleii are excited and upon deexcitation, 20 to 30 neutrons are expelled per nucleus.

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Inside the instrument a material will be positioned for investigation. Neutrons travel into the material and are detected when they come out. The directions in which the neutrons emerge tell us about the arrangement of the atoms inside. This is called neutron diffraction. The amount of energy lost by the neutrons as they travel through the material tells us about the atomic dynamics, a technique called neutron spectroscopy.

ISIS Accelerators and Targets

There are also two muon beamlines

https://www.isis.stfc.ac.uk/Pages/home.aspx

H- ion source (17 kV)

665 kV H- RFQ

70 MeV H- linac

800 MeV proton synchrotron

Extracted proton beam lines

Targets

Moderators

Pulsed beam of 800 MeV (84% speed of light) protons at 50 Hz

Average beam current is 230 muA (2.9× 1013 ppp)

184 kW on target (148 kW to TS-1 at 40 pps, 36 kW to TS-2 at 10 pps)

P = 800 (MV) x 230 (mA) = 184 (kW)

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Calculating beam power

Power (P) = Work/time = W/T

Work (W) = force x distance = Fd

Force on particle in an electric field (F) = qE

We know the electric field is (voltage/distance) and the protons (charge +1) have gained 800 MeV, so V=800MV.

We also know current (I) = charge/time = q/t

P = 800 (MV) x 230 (mA) = 184 (kW)

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Image courtesy ISIS, STFC.

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Unblocking oil pipes

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Stresses in Airbus A380 Wing

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Understanding infant lung structure

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5. Energy and Security Applications

Cargo scanning

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Materials testing for fusion

Source: IFMIF.org

“deuterium-tritium nuclear fusion reactions will generate neutron fluxes in the order of 1018 m-2s-1 with an energy of 14.1 MeV that will collide with the first wall of the reactor vessel”

International Fusion Material Irradiation Facility (IFMIF)

40 MeV

2 x 125mA linacs

CW deuterons, 5MW each

Beams will overlap onto a liquid Li jet

To create conditions similar to in a fusion reactor

To de-risk IFMIF, first a test accelerator ‘LIPAc’ is being built

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Installation of ‘LIPAc’ test accelerator has started in Japan

Accelerator Driven Systems

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Thorium is 3 times as abundant on earth and we use all of it (not 0.71% like uranium)

Fertile not fissile, add neutrons from accelerator to create U233 (fissile)

6. Historical and cultural applications

Radiocarbon Dating

1) As plants uptake C through photosynthesis, they take on the 14C activity of the atmosphere.

2) Anything that derives from this C will also have atmospheric 14C activity (including humans).

3) If something stops actively exchanging C (it dies, is buried, etc), that 14C begins to decay.

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Accelerators can study art

http://www.javno.com/en-bestseller/van-gogh-first-victim-of-particle-bombarding_185316

By directing synchrotron radiation onto 0.5 square mm ‘pixels’, it was possible to produce X-ray fluorescence intensity maps, reflecting the distribution of specific elements in the paint layers. In particular, the distribution of Hg mercury (red pigment) and Sb antimony (yellow pigment) allowed a reconstruction of the underlying image to be made.

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Accelerators can help spot art forgeries

An ion beam (usually, though not exclusively, protons) with MeV energy is directed onto the surface. A variety of backscattered radiation can give a detailed analysis of the atoms present in the surface.

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Accelerators in archaeology

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Accelerators can make food taste better

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Finally, just one more application…

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Next time someone asks you what accelerators are for…

“A beam of the right particles with the right energy at the right intensity can shrink a tumour, produce cleaner energy, spot suspicious cargo, make a better radial tire, clean up dirty drinking water, map a protein, study a nuclear explosion, design a new drug, make a heat-resistant automotive cable, diagnose a disease, reduce nuclear waste, detect an art forgery, implant ions in a semiconductor, prospect for oil, date an archaeological find, package a Thanksgiving turkey or…

…discover the secrets of the universe.”

-Accelerators for Americas Future Report, pp. 4, DoE, USA, 2011

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Source (2007): http://www.worldscientific.com/worldscibooks/10.1142/6272

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